Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts with the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment intera... https://giordanou642ltb8.wikimillions.com/user