Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions, whi... https://australianm419emu5.azzablog.com/profile