Heterosynaptic eLTD takes place at synapses adjacent into the stimulated synapses. By way of example, stimulation of Schaffer collaterals in hippocampal CA1 leads to a persistent lessen in GABAergic inhibition of CA1 pyramidal neurons (106). The mechanism of eLTD at hippocampal inhibitory synapses seems to involve inhibition of adenylyl cyclase https://juliusoyhmb.wssblogs.com/32770468/fascination-about-cannabinoids